Seismic isolation strategies were developed in Armenia due to the efforts of the author of this paper. Many medium and high-rise base isolated buildings were constructed in different regions of the country. Among them there are multi-story residential and business center complexes with parking floors and with floors envisaged for offices, shopping centers, fitness clubs, etc. Some complexes are briefly mentioned in the paper. However, the main information in this paper is given to describe the 7-story base isolated “Tufenkian” building with non-symmetric plan of the multifunctional hotel/commercial center complex constructed in the city of Yerevan. The complex has unique structural concept, including the suggested by the author approach on installation by clusters of seismic isolation laminated rubber-steel bearings (SILRSBs) in seismic isolation interface of this building. Some details of the suggested concepts and construction peculiarities are described. Also, some results of the earthquake response analyses are given. The building was analyzed using several time histories and also according to the requirements of the Armenian Seismic Code.