COVID-19 (coronavirus disease) has ravaged the world in a way that no previous pandemic in the past 50 years has. Since the epidemic, our knowledge of the illness has advanced significantly; multiorgan involvement has the greatest influence on disease prognosis. A rapidly developing respiratory condition that is characterized by severe inflammation and damage to the lungs, resulting in difficulty breathing and reduced oxygen levels in the blood, cardiac failure, liver failure, renal damage, shock, and multi-organ failure all increase morbidity and mortality. Hyperinflammatory response, characterized by elevated cytokine levels, may have a role in the pathophysiology of COVID-19 illness. One of the most prominent markers of C is 'cytokine storm syndrome.' The link between COVID-19 interferon-alpha, beta, and interferon-gamma tumor necrosis factor and significant cytokine families are examined in this study. We examine cytokine sources and biological roles while addressing numerous changes in immune response cellular components that correlate with cytokine levels. Lastly, we briefly explore future therapeutics aimed at modulating the cytokine storm.