The Covid-19 infection which was caused by severe acute respiratory syndrome coronavirus 2 continue to exit in 2024. Even with widely researches and vaccines developed, Covid-19 infection is far from being fully controlled. It is important to promote vaccination first, then early detection and treatment next. The medical providers, patients, community and public health systems must work together to prevent future Covid-19 infection. This article discusses the complexities of preventing Covid-19 infection and highlights the importance of continuous efforts.