Research Article

LIVER-PROTECTIVE POTENTIAL OF POLYPHENOL-RICH HERBAL MIXTURES: A STUDY ON ANTIOXIDANT AND ANTIPROLIFERATIVE ACTIVITIES

ISSN: 3067-3313

DOI Prefix: 10.5281/zenodo.

Authors: Aïssata Clarisse Kaboré, Koudbi Bérenger Zongo
Published: Volume 1, Issue 1 (2025)
Date: February 10, 2025

Abstract

Liver diseases, encompassing conditions such as cirrhosis, viral hepatitis, and liver cancer, exact a staggering toll on global health, contributing to at least two million deaths annually (Devarbhavi et al., 2023). Liver cancer, in particular, stands as the fourth leading cause of cancer-related mortality worldwide (Borrello and Mann, 2022). Among the myriad factors implicated in the pathogenesis of liver diseases, reactive oxygen species (ROS) and reactive nitrogen species (RNS) play pivotal roles, serving as by-products of oxygen and nitrogen metabolism, respectively (Li et al., 2015; Ramos-Tovar and Muriel, 2020). While ROS are integral to various physiological processes, including microbial defense mechanisms and signal transduction pathways, their excessive production can lead to oxidative stress and subsequent tissue damage, contributing to the development and progression of liver diseases.