Prostatitis has been observed to be common among men and efforts on therapeutic approach using local plants for management have attained a significant insight in research. In this work, using animal mode, Benign Prostate Hyperplasia (BPH) was induced with testosterone and the progress was monitored by treating with extract of Moringa oleifera. The enzymatic activities of three antioxidants were monitored spectrophotometrically and evaluated. An increased antioxidant activity was observed for Malondialdehyde (MDA), Sodium Dismutase (SOD) and Glutathione (GSH) which is suggestive of ameliorative property of Moringa Oleifera. With a P-value set at 0.05, a significant difference was observed for mean GSH on day 10, 20 and 25 in concentration. Similar observation was seen in Malondialdehyde and SOD.