The study evaluated the Nnamdi Azikiwe University Teaching Hospital's midwives' compliance with the W.H.O. Guidelines for maternity waste management practices. The study used a sample of seventy midwives and nurses. The study employed a descriptive research design. The study only employed one hypothesis and one research question. Data collection involved the use of a single research instrument. While the t-test was used to test the hypothesis, descriptive statistics such as percentage, mean, and charts were used to answer the research question. The findings showed that, of the 70 respondents, 55.7% were between the ages of 18 and 28, 25.71% were between the ages of 29 and 39, 18.6% were between the ages of 40 and 50, and none were 51 years of age or older. Of the respondents, 16% were men and 84% were women. Among the medical professions, 34% were doctors, 34% were nurses, 16% were waste handlers, and 16% were lab scientists. The study also showed that few respondents (21.4%) reported low compliance with HCW disposal, while the majority (78.6%) reported high compliance. Poor post-sign designation of HCW disposal and the absence of a well-constituted supervisory/monitoring nurses' group on HCW management are among the factors that work against proper waste disposal in Nnamdi Azikiwe University Teaching Hospital. According to the study's findings, midwives and nurses at Nnamdi Azikiwe University Teaching Hospital in Nnewi follow WHO guidelines when it comes to waste management practices. As a result, the study suggests that hospital administration develop thorough and ongoing training programs for midwives that concentrate on WHO guidelines for managing healthcare waste. Training ought to include handling, disposing, and properly classifying waste as well as how to use personal protective equipment.