Many bacterial species have been reported to develop resistance to antibiotics commonly prescribed for urinary tract infections. Therefore, the need to search for natural alternative for remedy of this problem cannot be overemphasized. One hundred and thirty-one (131) suspected E. coli and Klebsiella sp. were collected from patients with suspected urinary tract infection from the three major hospitals in Kano State. Purification and identification of the bacterial isolates were carried out using standard microbiological methods. Basic biochemical tests and MicroGen identification kit were used identification of the isolates. The antibiotic susceptibilities of the E coli and Klebsiella sp. was determined using the modified Kirby-Bauer diffusion method and the multidrug resistant isolates, extended drug resistance as well as pandrug resistance were determined using standard microbiological methods. Multiple antibiotic resistance (MAR) index is a measure of the extent of antimicrobial agent resistance for the isolates in the group studied. It was calculated as a/b, where a represents the number of antibiotics to which the isolates were resistant and b represents the total number of antibiotics to which the isolate was exposed. Out of the 131 isolates collected from the three major hospitals, 42.8%, 24.4% and 32.8% were obtained from Murtala Muhammad specialist hospital, Aminu teaching hospital and MuhammaAbdullahi Wase teaching hospital respectively. The biochemical tests showed that 30 (30.9 %) E coli, 10 (10.3) % Klebsiella sp, 29 (29 %), other Enterobacteriaceae, 28 (28.9) % non- Enterobacteriaceae. Of the 10 Klebsiella sp, 8 (80 %) were K oxytoca while 2 (20 %) were K pneumoniae. All the Klebsiella sp. and E coli isolates (n=40) were susceptible to gentamicin (100%), 75 % susceptible to ciprofloxacin and 67% to amoxicillin-clavulanic acid. The proportion of the isolates resistant to cephalothin was 77.5%, 72.5% to cefpodoxime, 57.5% to ampicillin, and 52.5 % to tetracycline. A total of 23 (57.5 %) of the isolates were multidrug resistant while 8 (20 %) of the multidrug isolates were extended drug resistant (XDR) with none being PDR. The isolates showed a high (77.5%) pre-exposure to antibiotics tested in this study at MARI ≥ 0.3. The Klebsiella spp. showed high (80%) preexposure to the antibiotics tested in this study than E. coli (76.7%) at MARI ≥ 0.3. MAR index varied considerably, the lowest index was 0.1 and the highest MAR index was 1.0. Which suggests that the isolates originated from environment where antibiotics are often used.