Premenstrual syndrome is all the symptoms occurring before the menstruation start.  Epidemiological surveys have estimated that as many as 80% of women of adolescent girls experience some symptoms attributed to the premenstrual phase of the menstrual cycle. The previous studies in India reported prevalence of PMS to be 20% in general population and severe symptoms in 8%. This study was aimed to assess the knowledge level of premenstrual syndrome with the view to develop an information booklet and find out association with the selected demographic variables among adolescent girls of Dayananda polytechnic college, Bangalore. The study is descriptive in nature which was conducted in Dayananda sagar Polytechnic College, Bangalore, Karnataka State, India. Thirty samples were selected by non-probability purposive sampling technique and a structured questionnaire was provided to collect data regarding knowledge related to premenstrual syndrome. The findings of the study which revealed that, 14(46.6%) respondents had inadequate knowledge, 10(33.3%) respondents had moderate knowledge and 6(20%) respondents had adequate knowledge on premenstrual syndrome